Vaccine Persistence

Pathologists from Mass. General Hospital & Harvard Medical School Find mRNA COVID Vaccines in the Heart Tissue of Vaccinated Patients

“These results suggest that SARS-CoV-2 mRNA vaccines routinely persist up to 30 days from vaccination and can be detected in the heart.

Tissues were obtained at autopsy from 20 post-vaccinated patients and 5 non-vaccinated control patients…all tissue samples with detectable vaccine mRNA were screened for the SARS-CoV-2 virus E gene and were found to be negative for the virus. Vaccine was not detected by RT-qPCR in any of the tissues from the 5 non-vaccinated control patients.

An important finding in this study, was the detection of SARS-CoV-2 vaccine mRNA in human heart tissue. Using an RT-qPCR assay, the BNT162b2 vaccine was detected in two left ventricular samples and two right ventricular samples from a total of three patients… All three of these patients had been vaccinated with BNT162b2 within 30 days of death.

Those patients with vaccine in the heart had more macrophages in the myocardium than those patients dying within 30 days of vaccination without vaccine in the heart.

In conclusion, this study provides a map of the biodistribution and persistence of SARS-CoV-2 mRNA vaccines in human tissues. A complete understanding of this biodistribution and time course of persistence will be essential as LNP-based vaccines become more widely used for a multitude of pathogens.”