NEW ARTICLE: IVERMECTIN and CANCER, it has at least 15 anti-Cancer mechanisms of action
9 Ivermectin papers reviewed: Ivermectin exerts anti-cancer effects through at least 15 different pathways proven in medical literature, both in vitro and in vivo!
Ivermectin induces tumor cell death: apoptosis, autophagy, pyroptosis
Ivermectin inhibits tumor initiation and tumor progression (via WNT inhibition, YAP1 inhibition)
Ivermectin inhibits tumor growth and proliferation (via Akt/mTOR inhibition, MAPK inhibition)
Ivermectin stops cancer cell migration, invasion and metastasis (via PAK1 inhibition)
Ivermectin causes cancer cell mitochondrial dysfunction
Ivermectin regulates tumor microenvironment Ivermectin kills or inhibits cancer stem cells (which are responsible for tumor initiation, progression and recurrence)
Ivermectin inhibits tumor angiogenesis (tumor blood vessel creation)
Ivermectin has anti-mitotic activity (interacts with mammalian tubulin)
Ivermectin is an epigenetic regulator of cancer to inhibit cancer progression
Ivermectin can overcome tumor multidrug resistance
What cancers can Ivermectin potentially treat?
The top 5 COVID-19 mRNA Vaccine Induced Turbo Cancers are: lymphomas, brain cancers, breast cancers (triple negative), colon cancers and lung cancers (signals also seen in leukemias, hepatobiliary cancers, testicular cancers, sarcomas, melanomas, renal cell, prostate)
Ivermectin has been shown to kill these cancer cells (in vitro or in vivo):
breast cancer, especially triple negative breast cancer which is often seen in COVID-19 mRNA Vaccinated women and has the worst prognosis.
glioblastoma and gliomas (glioblastomas are often seen in COVID-19 mRNA Vaccinated individuals)
leukemias, both AML and CML (these are the most aggressive and quickly lethal mRNA Turbo Cancers)
colorectal cancer (Stage 4 Colon cancers common in COVID-19 mRNA vaccinated)
hepatobiliary cancers: hepatocecullar carcinoma, cholangiocarcinoma, pancreatic cancer (major signals with COVID-19 mRNA Vaccine Turbo Cancers)
lung cancer (Stage 4 lung cancers in COVID-19 mRNA Vaccinated)
melanoma (definite signal in COVID-19 mRNA vaccinated)
renal cell cancer (possible signal with mRNA Turbo Cancers) and urothelial carcinoma
ovarian cancer (possible signal with mRNA Turbo Cancers) gastric cancer prostate cancer (possible signal with mRNA Turbo Cancers)
Nasopharyngeal cancer
I believe that it is a reasonable hypothesis that COVID-19 mRNA Vaccine Turbo Cancer patients could benefit from SAFE High Dose Ivermectin regimens, such as 2mg/kg and we urgently need more research to be done in this area.
Papers reviewed:
- 2023 Sep.23 – Man-Yuan Li et al – Ivermectin induces nonprotective autophagy by downregulating PAK1 and apoptosis in lung adenocarcinoma cells
- 2023 May – Samy et al – Eprinomectin: a derivative of ivermectin suppresses growth and metastatic phenotypes of prostate cancer cells by targeting the β-catenin signaling pathway
- 2022 Nov – Lotfalizadeh et al – The Anticancer potential of Ivermectin: Mechanisms of action and therapeutic implications
- 2022 Oct – Jian Liu et al – Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin
- 2022 Jun – Daeun Lee et al – Ivermectin suppresses pancreatic cancer via mitochondria dysfunction
- 2021 Aug – Shican Zhou et al – Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth
- 2021 Jan – Mingyang Tang et al – Ivermectin, a potential anticancer drug derived from an antiparasitic drug
- 2019 Sep Intuyod et al – Anti-parasitic Drug Ivermectin Exhibits Potent Anticancer Activity Against Gemcitabine-resistant Cholangiocarcinoma In Vitro
- 2018 Feb – Juarez et al – The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
Source: Dr. William Makis MD
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